Pacemaker current exists in ventricular myocytes.
نویسندگان
چکیده
I(f), the "cardiac pacemaker current," is a nonselective cation channel activated on hyperpolarization in primary and secondary pacemaker regions of the mammalian heart. The cardiac pacing rate can be modulated by shifting the activation of I(f) to more positive (faster pacing) or more negative (slower pacing) voltages. We report for the first time the presence of this pacemaker current in ventricular myocytes. The potential importance of this observation to the mechanism of differentiation of nonpacing regions in the heart is discussed.
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عنوان ژورنال:
- Circulation research
دوره 72 1 شماره
صفحات -
تاریخ انتشار 1993